Topoisomerase 2 alpha

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August undefined, 2024

WebThe chromosome scaffold is a structural and organizational component of mitotic chromosomes. It comprises proteins that occupy the chromatid core and display a … WebMar 9, 2024 · DNA topoisomerase 2-alpha, DNA Topoisomerase II alpha, DNA topoisomerase II, alpha isozyme. GeneRIFs: Gene References Into Functions. …

Topoisomerase 2 Alpha Cooperates with Androgen …

WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and … WebSep 1, 2015 · The aim of this study was to investigate association between expressions of multidrug resistance protein (MRP) and topoisomerase 2 alpha expression in non-small cell lung cancer (TOP2A) and brain metastasis operatively. The expression of MRP and TOP2A were performed using immunohistochemistry (IHC) staining, and the results were … book mix it up

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WebTopoisomerase Inhibitors. Compounds that inhibit the activity of DNA TOPOISOMERASES. A cytotoxic drug used as an adjunct for chemotherapy induction in the treatment of refractory childhood acute lymphoblastic leukemia. An antineoplastic enzyme inhibitor used to treat metastatic carcinoma of the colon or rectum. WebOct 13, 2024 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein on luminal breast cancer and its utility as an independent prognostic marker. Immunohistochemical expression of Top 2 A in breast … WebEuropium-labeled mouse monoclonal antibody recognizing human DNA Topoisomerase 2-alpha phosphorylated at Thr1342. Sequence motif recognized: DEK(pT)DDE book mla cite

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Topoisomerase Inhibitors DrugBank Online

WebAnti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) Research with confidence – consistent and reproducible results with every batch. Long-term and scalable supply – powered by recombinant technology for fast … WebMar 21, 2024 · TOP2A (DNA Topoisomerase II Alpha) is a Protein Coding gene. Diseases associated with TOP2A include Malignant Peripheral Nerve Sheath Tumor and … book mla citation exampleWebMay 5, 2014 · cancer agent to target human DNA topoisomerase 2-alpha. Lalit Mohan Nainwal 1, Pratap Parida 2, Aparoo p Das 1 and ParthaSarathi Bairy 1. 1 Department of Pharmaceutical Sciences, ... god talks with arjuna audio

"WebTopoisomerase 2 alpha (TOP2A) is considered to be the molecular target of these drugs. The potential predictive value of TOP2A amplification and overexpression has been extensively studied in breast cancer patients treated with anthracyclines. However, results are not conclusive. In this paper, we review some of the published studies addressing ... " - Topoisomerase 2 alpha

Topoisomerase 2 alpha

There are two subclasses of type II topoisomerases, type IIA and IIB. • Type IIA topoisomerases include the enzymes DNA gyrase, eukaryotic topoisomerase II (topo II), and bacterial topoisomerase IV (topo IV). These enzymes span all domains of life and are essential for function. • Type IIB topoisomerases are structurally and biochemically distinct, and comprise a single family member, topoisomerase VI (topo VI). Type IIB topoisomerases are found in archae… WebProtein target information for DNA topoisomerase 2-alpha (human). Find diseases associated with this biological target and compounds tested against it in bioassay experiments.

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WebTarget Information. Topo II alpha plays important roles in synthesis and transcription of DNA as well as chromosomal segregation during mitosis. It is reported to be a sensitive and specific marker of late S-, G2 and M-phases in transformed and developmentally regulated normal cellsTopo II alpha is also implicated in drug resistance of tumor ... WebThe topo II-alpha index correlates better with the MIB1 index than with the S-phase fraction or mitotic index. The topo II-alpha expression in breast cancer ranges from low (topo II-alpha index <1) to high (topo II-alpha index = 86). Amplification of c-erbB-2 was observed in 4 of 28 cases (14%) but did not correlate with high topo II-alpha indices.

WebNov 15, 2024 · Keith, W. N., Tan, K. B. & Brown, R. Amplification of the topoisomerase II alpha gene in a non-small cell lung cancer cell line and characterisation of polymorphisms at the human topoisomerase II ... WebMay 22, 2013 · Background Topoisomerase II alpha (Top 2 A) protein has been shown to be a proliferation marker associated with tumour grade. The current study evaluated the prognostic impact of Top 2 A protein ...

Webtopoisomerase (DNA) II alpha nucleus, response to DNA damage stimulus, nucleotide binding, nucleoplasm, ATP binding, protein complex, DNA binding, nucleolus, positive regulation of apoptotic process, protein homodimerization activity, drug binding, metal ion binding, magnesium ion binding, sequence-specific DNA binding, positive regulation of … WebAll lanes : Anti-Topoisomerase II alpha antibody [EP1102Y] (ab52934) at 1/1000 dilution Lane 1 : HeLa (human cervix adenocarcinoma) whole cell lysate Lane 2 : Jurkat (human acute T cell leukemia) whole cell lysate …

WebControl of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. ...

WebNov 11, 2015 · DNA topoisomerase 2 alpha (TOP2A) is an essential nuclear enzyme, required for resolution of topological stress associated with DNA replication. TOP2A introduces transient double strand breaks (DSB) on DNA in an ATP-dependent fashion to allow changes in DNA topology and eliminate over-winding [1,2]. TOP2A function is crucial … god talks to moses face to faceWebThe topo II-alpha index correlates better with the MIB1 index than with the S-phase fraction or mitotic index. The topo II-alpha expression in breast cancer ranges from low (topo II … god talks with arjuna hardbackWebDoussis-Anagnostopoulou IA, Vassilakopoulos TP, Thymara I, et al. Topoisomerase II alpha expression as an independent prognostic factor in Hodgkin’s lymphoma. Clin Cancer Res. … god talked to moses face to faceWebMay 4, 2001 · Subunit. Homodimer. Interacts with COPS5. Interacts with RECQL5; this stimulates DNA decatenation. ... god talk sid rothWebApr 9, 2024 · The tyrosyl-DNA phosphodiesterase 1 (TDP1) enzyme hydrolyzes the phosphodiester bond between a tyrosine residue and the 3′-phosphate of DNA in the DNA–topoisomerase I (TopI) complex, being involved in different DNA repair pathways. A small TDP1 gene subfamily is present in plants, where TDP1α has been … god talks with arjuna the bhagavad gita pdfDNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene. Topoisomerase IIα relieves topological DNA stress during transcription, condenses chromosomes, and separates chromatids. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands … See more TOP2A has been shown to interact with SMURF2, HDAC1, CDC5L, Small ubiquitin-related modifier 1, P53, and TOPBP1. See more In Drosophila Hadlaczky et al 1988 found DNA topoisomerase II α to correlate with cell proliferation - but β did not. See more • Watt PM, Hickson ID (November 1994). "Structure and function of type II DNA topoisomerases". The Biochemical Journal. 303 (Pt 3): 681–695. doi:10.1042/bj3030681 See more • Topoisomerase II • TOP2B - Topoisomerase II beta • Gene duplication • Ataxia-telangiectasia See more god talking to people in the bibleWebJun 15, 2012 · To better understand how these enzymes act in both contexts, we determined the 2.9-Å-resolution structure of the DNA … god talks to job out of the whirlwind